Can sleep deprivation alleviate depression?

Yes, but only temporarily:

Via the WSJ:

Brain scans also showed that the subjects who had pulled all-nighters had heightened activity in the mesolimbic pathway, a brain circuit driven by dopamine, a neurotransmitter that typically regulates feelings of pleasure, addiction and cravings.

The boost of dopamine after an all-nighter may help explain why sleep deprivation can alleviate major depression in about 60% of patients, although the effect is only temporary. “As soon as they get recovery sleep, all that mood elevation is lost,” says Dr. Walker.

And there are other reasons it may not be a good idea:

Although the feelings of euphoria sound great, Dr. Walker warns that operating more on emotion than reason can be very risky. “You are all gas pedal and no brake,” he says. That can be dangerous, indeed, if you are in a job that requires both long hours and difficult decision making.

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